Development of the adhesive composition for the transdermal therapeutic system with the anti-inflammatory action

Aim. To develop the content of adhesive composition, being one stages in developing transdermal therapeutic system with anti-inflammatory action. Materials and methods. Using organoleptic research methods, properties affecting process applying to base subsequently quality finished product were studied. Color, consistency homogeneity determined visually, features mass recorded. determine optimal temperature drying time, was performed a thermostat at 60 120 ºС for 5-15 min. Results discussion. Compositions based on mixture hydrogels hydrophobic silicone had very thick consistency, which made it difficult apply them led significant weight losses during application. Instead, compositions aesilonum-aerosil too liquid consistency. Adjusting amount aesilonum-4 we obtained composition satisfactory consistent properties, distributed over uniform thin layer. When studying effect enhancers found that addition oleic acid dimethyl sulfoxide diluted themass prevented application base, isopropyl myristate slightly mass, while propylene glycol did not affect all. Therefore, could be used as an enhancer. setting extension mode, 5 Conclusions. The has been developed. includes: polysiloxane – 5.0, H-polysiloxane aerosil 0.35, 1.0, 1.0. It properties. mode is